Visible-light-induced cleavage of 4-α-amino acid substituted naphthalimides and its application in DNA photocleavage

Jin Zhou; Canliang Fang; Ying Liu; Yao Zhao; Nan Zhang; Xiangjun Liu; Fuyi Wang; Dihua Shangguan

doi:10.1039/c5ob00302d

Visible-light-induced cleavage of 4-α-amino acid substituted naphthalimides and its application in DNA photocleavage

Org Biomol Chem. 2015 Apr 7;13(13):3931-5. doi: 10.1039/c5ob00302d.

Authors

Jin Zhou¹, Canliang Fang, Ying Liu, Yao Zhao, Nan Zhang, Xiangjun Liu, Fuyi Wang, Dihua Shangguan

Affiliation

¹ Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China. sgdh@iccas.ac.cn.

PMID: 25712431
DOI: 10.1039/c5ob00302d

Abstract

A new kind of visible-light photocleavable molecule, 4-α-amino acid substituted naphthalimide, is reported. The cleavage occurred at the C-N bond between the 4-amino and the amino acid residue and released a 4-aminonaphthalimide. A lysine substituted naphthalimide exhibited a strong DNA photocleavage activity when irradiated with a blue light LED.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acids / chemistry*
DNA / chemistry*
DNA Cleavage*
Light*
Naphthalimides / chemistry*
Photochemical Processes*

Substances

Amino Acids
Naphthalimides
DNA