YAP and the drug resistance highway

Nat Genet. 2015 Mar;47(3):193-4. doi: 10.1038/ng.3228.

Abstract

Deciphering mechanisms of drug resistance is crucial to winning the battle against cancer. A new study points to an unexpected function of YAP in drug resistance and illuminates its potential role as a therapeutic target.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Adaptor Proteins, Signal Transducing / genetics*
  • Animals
  • Female
  • Hippo Signaling Pathway
  • Humans
  • MAP Kinase Kinase Kinases / antagonists & inhibitors*
  • Phosphoproteins / genetics*
  • Protein Kinase Inhibitors / pharmacology*
  • Protein Serine-Threonine Kinases / genetics*
  • Proto-Oncogene Proteins B-raf / antagonists & inhibitors*
  • Transcription Factors
  • YAP-Signaling Proteins

Substances

  • Adaptor Proteins, Signal Transducing
  • Phosphoproteins
  • Protein Kinase Inhibitors
  • Transcription Factors
  • YAP-Signaling Proteins
  • YAP1 protein, human
  • BRAF protein, human
  • Protein Serine-Threonine Kinases
  • Proto-Oncogene Proteins B-raf
  • MAP Kinase Kinase Kinases