Abstract
Deciphering mechanisms of drug resistance is crucial to winning the battle against cancer. A new study points to an unexpected function of YAP in drug resistance and illuminates its potential role as a therapeutic target.
Publication types
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Research Support, Non-U.S. Gov't
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Comment
MeSH terms
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Adaptor Proteins, Signal Transducing / genetics*
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Animals
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Female
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Hippo Signaling Pathway
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Humans
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MAP Kinase Kinase Kinases / antagonists & inhibitors*
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Phosphoproteins / genetics*
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Protein Kinase Inhibitors / pharmacology*
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Protein Serine-Threonine Kinases / genetics*
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Proto-Oncogene Proteins B-raf / antagonists & inhibitors*
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Transcription Factors
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YAP-Signaling Proteins
Substances
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Adaptor Proteins, Signal Transducing
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Phosphoproteins
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Protein Kinase Inhibitors
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Transcription Factors
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YAP-Signaling Proteins
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YAP1 protein, human
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BRAF protein, human
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Protein Serine-Threonine Kinases
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Proto-Oncogene Proteins B-raf
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MAP Kinase Kinase Kinases