The association of LOXL1 polymorphisms with exfoliation syndrome/glaucoma: Meta-analysis

Qing-Shan Ji; Bing Qi; Yue-Chun Wen; Lian Liu; Xiao-Ling Guo; Guo-Cheng Yu; Jing-Xiang Zhong

doi:10.3980/j.issn.2222-3959.2015.01.27

The association of LOXL1 polymorphisms with exfoliation syndrome/glaucoma: Meta-analysis

Int J Ophthalmol. 2015 Feb 18;8(1):148-56. doi: 10.3980/j.issn.2222-3959.2015.01.27. eCollection 2015.

Authors

Qing-Shan Ji¹, Bing Qi², Yue-Chun Wen¹, Lian Liu², Xiao-Ling Guo³, Guo-Cheng Yu², Jing-Xiang Zhong²

Affiliations

¹ Department of Ophthalmology, Affiliated Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, Anhui Province, China.
² Department of Ophthalmology, the First Affiliated Hospital of Jinan University, Guangzhou 510632, Guangdong Province, China.
³ Department of Cell Biology, the Cell Biology Institute of Jinan University, Guangzhou 510632, Guangdong Province, China.

PMID: 25709925
PMCID: PMC4325259
DOI: 10.3980/j.issn.2222-3959.2015.01.27

Abstract

Aim: To investigate the association of lysyl oxidase-like 1 (LOXL1) single nucleotide polymorphisms (SNPs) with exfoliation syndrome (XFS)/exfoliation glaucoma (XFG).

Methods: Published manuscripts from PubMed and EMBASE were identified until May 2014. Summary odds ratios (ORs) and 95% confidence intervals (CIs) for LOXL1 (rs1048661, rs2165241 and rs3825942) polymorphisms and the risk of XFS/XFG were estimated using random- or fixed- effect model.

Results: The three LOXL1 polymorphisms (rs1048661, rs3825942, and rs2165241) were associated with an increased risk for XFS/XFG among Caucasians, with OR 2.19(1.96-2.45), 8.8 (6.05-12.79) and 3.41 (3.11-3.73), respectively. On the contrast, the rs1048661 and rs2165241, but not rs3825942 polymorphism, have a potential protective effect on XFS/XFG in Asians, with OR 0.06 (0.02-0.18), 0.15 (0.09-0.25), respectively.

Conclusion: There is strong evidence that LOXL1 polymorphisms are associated with XFS/XFG risk. The strength of risk might be ethnicity-dependent.

Keywords: Meta-analysis; exfoliation syndrome; glaucoma; lysyl oxidase-like 1; polymorphism.

Publication types

Retracted Publication