Sex-discordant monochorionic twins with blood and tissue chimerism

David Rodriguez-Buritica; Kitiwan Rojnueangnit; Ludwine M Messiaen; Fady M Mikhail; Nathaniel H Robin

doi:10.1002/ajmg.a.37022

Sex-discordant monochorionic twins with blood and tissue chimerism

Am J Med Genet A. 2015 Apr;167A(4):872-7. doi: 10.1002/ajmg.a.37022. Epub 2015 Feb 23.

Authors

David Rodriguez-Buritica¹, Kitiwan Rojnueangnit, Ludwine M Messiaen, Fady M Mikhail, Nathaniel H Robin

Affiliation

¹ Division of Genetics, Department of Pediatrics, School of Medicine University of Texas at Houston, Houston, Texas; Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama.

PMID: 25708669
DOI: 10.1002/ajmg.a.37022

Abstract

We report on a pair of normally conceived monochorionic/dizygotic (MC/DZ) sex discordant twins. The comparison of blood and skin genotypes revealed that the chimerism was also present in the skin. We conjecture about the developmental origins of this case.

Keywords: chimerism; monochorionic/dizygotic twin pregnancy; spontaneously conceived MC/DZ twins; twin-twin transfusion syndrome.

Publication types

Case Reports
Twin Study

MeSH terms

46, XX Disorders of Sex Development / diagnosis*
46, XX Disorders of Sex Development / genetics
Abnormalities, Multiple / diagnosis*
Abnormalities, Multiple / genetics
Chimerism
Female
Humans
Infant
Male
Polymorphism, Single Nucleotide
Skin / pathology
Twins, Dizygotic / genetics*