Bioactive benzofuran derivatives: An insight on lead developments, radioligands and advances of the last decade

Ashish Radadiya; Anamik Shah

doi:10.1016/j.ejmech.2015.01.021

Bioactive benzofuran derivatives: An insight on lead developments, radioligands and advances of the last decade

Eur J Med Chem. 2015 Jun 5:97:356-76. doi: 10.1016/j.ejmech.2015.01.021. Epub 2015 Jan 13.

Authors

Ashish Radadiya¹, Anamik Shah²

Affiliations

¹ Department of Chemistry, Saurashtra University, University Road, Rajkot 360005, Gujarat, India.
² Department of Chemistry, Saurashtra University, University Road, Rajkot 360005, Gujarat, India. Electronic address: anamik_shah@hotmail.com.

PMID: 25703339
DOI: 10.1016/j.ejmech.2015.01.021

Abstract

Benzofuran core is a highly versatile, presents in many important natural products and natural drugs. Many benzofuran containing synthetic drugs and clinical candidates have been derived from natural products. The present review will provide an insight on lead design-developments of the decade, clinical candidates and PET tracer radio-ligands containing benzofuran core along with brief target biology. Brief of the all approved drugs containing benzofuran core also have been enclosed. Main therapeutic areas covered are Cancer, Neurological disorders including anti-psychotic agent and diabetes.

Keywords: Benzofuran; CNS; Cancer; Coumarone; Diabetes; PET imaging.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Benzofurans / chemistry
Benzofurans / pharmacology*
Biological Products / chemistry
Biological Products / pharmacology*
Drug Design*
Drug Discovery
Humans
Radiopharmaceuticals / chemistry
Radiopharmaceuticals / pharmacology*

Substances

Benzofurans
Biological Products
Radiopharmaceuticals
benzofuran