Novel fused tetrathiocines as antivirals that target the nucleocapsid zinc finger containing protein of the feline immunodeficiency virus (FIV) as a model of HIV infection

Bioorg Med Chem Lett. 2015 Mar 15;25(6):1352-5. doi: 10.1016/j.bmcl.2014.12.047. Epub 2014 Dec 20.

Abstract

A novel series of fused tetrathiocines were prepared for evaluation of activity against the nucleocapsid protein of the feline immunodeficiency virus (FIV) in an in vitro cell culture approach. The results demonstrated that the compounds display potent nanomolar activity and low toxicity against this key model of HIV infection.

Keywords: FIV; HIV; Nucleocapsid; Tetrathiocenes; Zinc finger.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antiviral Agents / chemistry*
  • Antiviral Agents / metabolism
  • Antiviral Agents / toxicity
  • Benzamides / chemistry*
  • Benzamides / metabolism
  • Benzamides / toxicity
  • Binding Sites
  • Cats
  • Cell Line
  • Cell Survival / drug effects
  • Disease Models, Animal
  • Immunodeficiency Virus, Feline / drug effects
  • Immunodeficiency Virus, Feline / metabolism*
  • Molecular Docking Simulation
  • Nucleocapsid Proteins / antagonists & inhibitors*
  • Nucleocapsid Proteins / metabolism
  • Protein Binding
  • Protein Structure, Tertiary
  • Sulfhydryl Compounds / chemistry*
  • Zinc Fingers

Substances

  • Antiviral Agents
  • Benzamides
  • Nucleocapsid Proteins
  • Sulfhydryl Compounds