[Structure of amyloid-beta peptides in a complex with model membranes]

Tsitologiia. 2014;56(6):453-5.
[Article in Russian]

Abstract

Structures of amyloid-beta peptides Aβ1-40, Aβ10-35, Aβ13-23 and Aβ16-22 in a complex with model membranes in solution were obtained on the analysis of NMR experimental data. It has been established that the process of peptide-micelle complex formation occurs through the amino acid residues L17, F19, F20 and G29-M35.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Amino Acids / chemistry*
  • Amyloid beta-Peptides / chemical synthesis
  • Amyloid beta-Peptides / chemistry*
  • Deuterium
  • Humans
  • Magnetic Resonance Spectroscopy
  • Membranes, Artificial
  • Micelles
  • Models, Molecular
  • Molecular Sequence Data
  • Peptide Fragments / chemical synthesis
  • Peptide Fragments / chemistry*
  • Protein Structure, Secondary
  • Sodium Dodecyl Sulfate / chemistry*
  • Solutions

Substances

  • Amino Acids
  • Amyloid beta-Peptides
  • Membranes, Artificial
  • Micelles
  • Peptide Fragments
  • Solutions
  • amyloid beta-protein (1-40)
  • amyloid beta-protein (10-35)
  • amyloid beta-protein (16-22)
  • Sodium Dodecyl Sulfate
  • Deuterium