Abstract
Contacts of persons infected with multidrug-resistant tuberculosis (MDR TB) have few prophylaxis options. Of 50 contacts of HIV- and MDR TB-positive persons who were treated with moxifloxacin, 30 completed treatment and 3 discontinued treatment because of gastrointestinal symptoms. Moxifloxacin was generally well-tolerated; further research of its efficacy against MDR TB is needed.
MeSH terms
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Antibiotic Prophylaxis*
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Antitubercular Agents / therapeutic use*
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Coinfection
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Fluoroquinolones / therapeutic use*
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Follow-Up Studies
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HIV Infections
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Humans
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Moxifloxacin
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Mycobacterium tuberculosis
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New York City / epidemiology
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Treatment Outcome
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Tuberculosis, Multidrug-Resistant / drug therapy*
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Tuberculosis, Multidrug-Resistant / epidemiology
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Tuberculosis, Multidrug-Resistant / prevention & control
Substances
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Antitubercular Agents
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Fluoroquinolones
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Moxifloxacin