Hydrazide macrocycles as effective transmembrane channels for ammonium

Chem Commun (Camb). 2015 Mar 21;51(23):4819-22. doi: 10.1039/c5cc00691k.

Abstract

Three shape-persistent aromatic hydrazide macrocycles that bear phenylalanine tripeptide chains have been synthesized. These macrocycles can insert into lipid bilayers to form single-molecular ion channels which exhibit a high NH4(+)/K(+) selectivity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ammonium Compounds / chemistry*
  • Computational Biology
  • Lipids / chemistry
  • Macrocyclic Compounds / chemical synthesis*
  • Macrocyclic Compounds / chemistry
  • Membranes, Artificial*
  • Molecular Structure
  • Phenylalanine / chemistry
  • Potassium / chemistry

Substances

  • Ammonium Compounds
  • Lipids
  • Macrocyclic Compounds
  • Membranes, Artificial
  • Phenylalanine
  • Potassium