Abstract
Three shape-persistent aromatic hydrazide macrocycles that bear phenylalanine tripeptide chains have been synthesized. These macrocycles can insert into lipid bilayers to form single-molecular ion channels which exhibit a high NH4(+)/K(+) selectivity.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Ammonium Compounds / chemistry*
-
Computational Biology
-
Lipids / chemistry
-
Macrocyclic Compounds / chemical synthesis*
-
Macrocyclic Compounds / chemistry
-
Membranes, Artificial*
-
Molecular Structure
-
Phenylalanine / chemistry
-
Potassium / chemistry
Substances
-
Ammonium Compounds
-
Lipids
-
Macrocyclic Compounds
-
Membranes, Artificial
-
Phenylalanine
-
Potassium