Cycloartane Glycosides from the Roots of Cimicifuga foetida with Wnt Signaling Pathway Inhibitory Activity

Di-Fan Zhu; Guo-Lei Zhu; Ling-Mei Kong; Ni-Man Bao; Lin Zhou; Yin Nian; Ming-Hua Qiu

doi:10.1007/s13659-015-0053-7

Cycloartane Glycosides from the Roots of Cimicifuga foetida with Wnt Signaling Pathway Inhibitory Activity

Nat Prod Bioprospect. 2015 Feb 19;5(2):61-67. doi: 10.1007/s13659-015-0053-7. eCollection 2015 Apr.

Authors

Di-Fan Zhu^#¹, Guo-Lei Zhu^#¹, Ling-Mei Kong¹, Ni-Man Bao¹, Lin Zhou¹, Yin Nian¹, Ming-Hua Qiu¹

Affiliation

¹ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 China.

^# Contributed equally.

Abstract

Four new 9,19-cycloartane triterpenoids, cimilactone E (1), cimilactone F (2), 2'-O-(E)-butenoyl-23-epi-26-deoxyactein (3), and 2',12β-O-diacetylcimiracemonol-3-O-β-d-xylopyranoside (4), together with four known constituents (5-8) were isolated from the roots of Cimicifuga foetida. The new structures were elucidated by extensive spectroscopic analysis. In addition, compounds 7 and 8 showed significant Wnt signaling pathway inhibitory activity, with IC₅₀ values of 3.33 and 13.34 μM, respectively, using the luciferase reporter gene assay.

Keywords: 9,19-Cycloartane triterpenoids; Cimicifuga foetida; Cimilactone-type; Luciferase activity; Wnt signal pathway.