Varicella-zoster meningitis with a late-onset of skin eruption

BMJ Case Rep. 2015 Feb 17:2015:bcr2014208056. doi: 10.1136/bcr-2014-208056.

Abstract

Viral meningitis caused by varicella-zoster virus (VZV) is an uncommon neurological complication of herpes zoster. It may occur before or after the onset of the vesicular rash along the dermatomal distribution, which is the classic presentation of herpes zoster. We describe a case of a 51-year-old immunocompetent Caucasian man who presented with neck and severe right-sided facial pain. Eight days later, he had photophobia and papular rash on his forehead. Cerebrospinal fluid (CSF) examination confirmed aseptic meningitis and CSF PCR detected the presence of VZV DNA. Neurological complications of VZV infection, such as aseptic meningitis, may be difficult to diagnose and can cause delay in treatment, especially in cases with late onset of dermatological manifestations of herpes zoster. Definite diagnosis requires evidence of acute VZV infection in blood or cerebrospinal fluid.

Publication types

  • Case Reports

MeSH terms

  • Acyclovir / analogs & derivatives
  • Acyclovir / therapeutic use
  • Antiviral Agents / therapeutic use
  • Diagnosis, Differential
  • Exanthema / diagnosis
  • Exanthema / drug therapy
  • Exanthema / etiology*
  • Herpes Zoster / complications*
  • Herpes Zoster / diagnosis
  • Herpes Zoster / drug therapy
  • Humans
  • Male
  • Meningitis, Viral / cerebrospinal fluid
  • Meningitis, Viral / etiology*
  • Middle Aged
  • Polymerase Chain Reaction
  • Valacyclovir
  • Valine / analogs & derivatives
  • Valine / therapeutic use

Substances

  • Antiviral Agents
  • Valine
  • Valacyclovir
  • Acyclovir