Abstract
Objective:
To observe the safety and efficacy of Colistimethate sodium in children infected with gram-negative bacteria, susceptible only to colistimethate sodium.
Methods:
This prospective observational study done over 2 years observed children who received colistin for >48 h, for renal failure as defined by p-RIFLE criteria.
Results:
Out of 68 children, 52 (76.5%) survived. There were three children with evidence of acute kidney injury and none had neurotoxicity. Serum creatinine significantly decreased at 48 h and at end of treatment, from that at beginning of therapy (P=0.007).
Conclusions:
Colistimethate sodium is effective against carbapenem-resistant Gram-negative bacteria, and is safe in children.
MeSH terms
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Acute Kidney Injury / chemically induced
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Acute Kidney Injury / epidemiology*
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Administration, Intravenous
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Adolescent
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / adverse effects*
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Anti-Bacterial Agents / pharmacology
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Anti-Bacterial Agents / therapeutic use
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Child
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Child, Preschool
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Colistin / administration & dosage
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Colistin / adverse effects
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Colistin / analogs & derivatives*
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Colistin / pharmacology
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Colistin / therapeutic use
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Creatinine / blood
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Drug Resistance, Bacterial
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Female
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Gram-Negative Bacteria / drug effects
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Gram-Negative Bacterial Infections / drug therapy*
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Gram-Negative Bacterial Infections / epidemiology
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Gram-Negative Bacterial Infections / microbiology
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Humans
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Infant
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Infant, Newborn
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Male
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Microbial Sensitivity Tests
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Prospective Studies
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Sepsis / drug therapy
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Sepsis / epidemiology
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Sepsis / microbiology
Substances
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Anti-Bacterial Agents
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Creatinine
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colistinmethanesulfonic acid
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Colistin