Safety and efficacy of intravenous colistin in children

Indian Pediatr. 2015 Feb;52(2):129-30. doi: 10.1007/s13312-015-0586-1.

Abstract

Objective: To observe the safety and efficacy of Colistimethate sodium in children infected with gram-negative bacteria, susceptible only to colistimethate sodium.

Methods: This prospective observational study done over 2 years observed children who received colistin for >48 h, for renal failure as defined by p-RIFLE criteria.

Results: Out of 68 children, 52 (76.5%) survived. There were three children with evidence of acute kidney injury and none had neurotoxicity. Serum creatinine significantly decreased at 48 h and at end of treatment, from that at beginning of therapy (P=0.007).

Conclusions: Colistimethate sodium is effective against carbapenem-resistant Gram-negative bacteria, and is safe in children.

MeSH terms

  • Acute Kidney Injury / chemically induced
  • Acute Kidney Injury / epidemiology*
  • Administration, Intravenous
  • Adolescent
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / adverse effects*
  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use
  • Child
  • Child, Preschool
  • Colistin / administration & dosage
  • Colistin / adverse effects
  • Colistin / analogs & derivatives*
  • Colistin / pharmacology
  • Colistin / therapeutic use
  • Creatinine / blood
  • Drug Resistance, Bacterial
  • Female
  • Gram-Negative Bacteria / drug effects
  • Gram-Negative Bacterial Infections / drug therapy*
  • Gram-Negative Bacterial Infections / epidemiology
  • Gram-Negative Bacterial Infections / microbiology
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Microbial Sensitivity Tests
  • Prospective Studies
  • Sepsis / drug therapy
  • Sepsis / epidemiology
  • Sepsis / microbiology

Substances

  • Anti-Bacterial Agents
  • Creatinine
  • colistinmethanesulfonic acid
  • Colistin