Abstract
Two new sesquiterpenoids, siegenolides A (1) and B (2), and two known sesquiterpenes 3 and 4 were isolated from Siegesbeckia glabrescens. Their structures were elucidated by spectroscopic analyses, and they were further evaluated for their cytotoxic activities against human cancer cells (MCF-7, AsPC-1, SW480, HCT 116, HepG2, HeLa). Compounds 1-4 showed differential cytotoxic effects on the target cancer cells with IC50 values in the range of 0.9-33.3 μM.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antineoplastic Agents, Phytogenic / chemistry
-
Antineoplastic Agents, Phytogenic / isolation & purification*
-
Antineoplastic Agents, Phytogenic / pharmacology*
-
Asteraceae / chemistry*
-
Cell Line, Tumor
-
Cell Survival / drug effects
-
HCT116 Cells
-
HeLa Cells
-
Hep G2 Cells
-
Humans
-
Inhibitory Concentration 50
-
MCF-7 Cells
-
Molecular Structure
-
Sesquiterpenes / chemistry
-
Sesquiterpenes / isolation & purification*
-
Sesquiterpenes / pharmacology*
Substances
-
Antineoplastic Agents, Phytogenic
-
Sesquiterpenes