Briarenolides K and L, new anti-inflammatory briarane diterpenoids from an octocoral Briareum sp. (Briareidae)

Yin-Di Su; Tzu-Rong Su; Zhi-Hong Wen; Tsong-Long Hwang; Lee-Shing Fang; Jih-Jung Chen; Yang-Chang Wu; Jyh-Horng Sheu; Ping-Jyun Sung

doi:10.3390/md13021037

Briarenolides K and L, new anti-inflammatory briarane diterpenoids from an octocoral Briareum sp. (Briareidae)

Mar Drugs. 2015 Feb 13;13(2):1037-50. doi: 10.3390/md13021037.

Authors

Yin-Di Su^{1

2}, Tzu-Rong Su^{3

4}, Zhi-Hong Wen⁵, Tsong-Long Hwang⁶, Lee-Shing Fang⁷, Jih-Jung Chen⁸, Yang-Chang Wu^{9

10

11

12}, Jyh-Horng Sheu¹³, Ping-Jyun Sung^{14

15

16

17

18}

Affiliations

¹ Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan. gobetter04@yahoo.com.tw.
² National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. gobetter04@yahoo.com.tw.
³ Department of Beauty Science, Meiho University, Pingtung 912, Taiwan. a081002@mail.tsmh.org.tw.
⁴ Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital, Pingtung 928, Taiwan. a081002@mail.tsmh.org.tw.
⁵ Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan. wzh@mail.nsysu.edu.tw.
⁶ Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.
⁷ Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan. lsfang@csu.edu.tw.
⁸ Department of Pharmacy, Tajen University, Pingtung 907, Taiwan. jjchen@tajen.edu.tw.
⁹ School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.
¹⁰ Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.
¹¹ Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. yachwu@mail.cmu.edu.tw.
¹² Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.
¹³ Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan. sheu@mail.nsysu.edu.tw.
¹⁴ Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan. pjsung@nmmba.gov.tw.
¹⁵ National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.
¹⁶ Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan. pjsung@nmmba.gov.tw.
¹⁷ Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. pjsung@nmmba.gov.tw.
¹⁸ Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.

Abstract

Two new briarane-type diterpenoids, briarenolides K (1) and L (2), were isolated from an octocoral identified as Briareum sp. The structures of new briaranes 1 and 2 were elucidated by spectroscopic methods. In the in vitro anti-inflammatory effects test, briaranes 1 and 2 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anthozoa / chemistry*
Anti-Inflammatory Agents, Non-Steroidal / chemistry
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
Chromatography, High Pressure Liquid
Diterpenes / chemistry
Diterpenes / pharmacology*
Enzyme Inhibitors / pharmacology
Lipopolysaccharides / antagonists & inhibitors
Magnetic Resonance Spectroscopy
Mice
Models, Molecular
Molecular Conformation
Nitric Oxide Synthase Type II / antagonists & inhibitors
RAW 264.7 Cells / drug effects
Spectrophotometry, Infrared

Substances

Anti-Inflammatory Agents, Non-Steroidal
Diterpenes
Enzyme Inhibitors
Lipopolysaccharides
briarenolide K
briarenolide L
Nitric Oxide Synthase Type II