Acredinones A and B, voltage-dependent potassium channel inhibitors from the sponge-derived fungus Acremonium sp. F9A015

J Nat Prod. 2015 Mar 27;78(3):363-7. doi: 10.1021/np5007586. Epub 2015 Feb 17.

Abstract

Two new benzophenones, acredinones A (1) and B (2), were isolated from a marine-sponge-associated Acremonium sp. fungus. Their chemical structures were elucidated on the interpretation of spectroscopic data. The structure of 1 was confirmed by palladium-catalyzed hydrogenation, followed by spectroscopic data analysis. Acredinones A (1) and B (2) inhibited the outward K(+) currents of the insulin secreting cell line INS-1 with IC50 values of 0.59 and 1.0 μM, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acremonium / chemistry*
  • Animals
  • Benzophenones / chemistry
  • Benzophenones / isolation & purification*
  • Benzophenones / pharmacology*
  • Drug Screening Assays, Antitumor
  • Humans
  • Inhibitory Concentration 50
  • Insulin / metabolism
  • Insulin Secretion
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Porifera / microbiology*
  • Potassium Channel Blockers / chemistry
  • Potassium Channel Blockers / isolation & purification*
  • Potassium Channel Blockers / pharmacology*

Substances

  • Benzophenones
  • Insulin
  • Potassium Channel Blockers
  • acredinone A
  • acredinone B