Abstract
Two new benzophenones, acredinones A (1) and B (2), were isolated from a marine-sponge-associated Acremonium sp. fungus. Their chemical structures were elucidated on the interpretation of spectroscopic data. The structure of 1 was confirmed by palladium-catalyzed hydrogenation, followed by spectroscopic data analysis. Acredinones A (1) and B (2) inhibited the outward K(+) currents of the insulin secreting cell line INS-1 with IC50 values of 0.59 and 1.0 μM, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acremonium / chemistry*
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Animals
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Benzophenones / chemistry
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Benzophenones / isolation & purification*
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Benzophenones / pharmacology*
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Drug Screening Assays, Antitumor
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Humans
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Inhibitory Concentration 50
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Insulin / metabolism
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Insulin Secretion
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Porifera / microbiology*
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Potassium Channel Blockers / chemistry
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Potassium Channel Blockers / isolation & purification*
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Potassium Channel Blockers / pharmacology*
Substances
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Benzophenones
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Insulin
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Potassium Channel Blockers
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acredinone A
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acredinone B