Abstract
Two new eudesmane-type glucopyranosides have been isolated from the fruits of Daucus carota L. On the basis of their spectroscopic and chemical evidence, the new compounds were elucidated as daucucarotol-10-O-β-D-glucopyranoside (1) and decahydro-7-[(2-O-β-D-glucopyranosyl)-isopropyl]-1β,4aα-dimethyl-(1α,4α,8aβ)-naphthalenetriol (2). Compounds 1 and 2 showed moderate antitumour activity against human ECA-109 and gave IC50 values of 23.22 and 26.76 μM, respectively.
Keywords:
Daucus carota L; antitumour activity; eudesmane type sesquiterpene glycoside.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antineoplastic Agents, Phytogenic / chemistry*
-
Antineoplastic Agents, Phytogenic / isolation & purification
-
Cell Line, Tumor
-
Daucus carota / chemistry*
-
Fruit / chemistry
-
Glucosides / chemistry*
-
Glucosides / isolation & purification
-
Humans
-
Molecular Structure
-
Sesquiterpenes, Eudesmane / chemistry*
-
Sesquiterpenes, Eudesmane / isolation & purification
Substances
-
Antineoplastic Agents, Phytogenic
-
Glucosides
-
Sesquiterpenes, Eudesmane
-
daucucarotol-10-O-glucopyranoside
-
decahydro-7-((2-O-glucopyranosyl)isopropyl)-1,4a-dimethyl-(1,4,8a)-naphthalenetriol
-
eudesmane