Corneal collagen cross-linking in keratoconus -- long-term prospective study

J Fr Ophtalmol. 2015 Mar;38(3):199-205. doi: 10.1016/j.jfo.2014.10.007. Epub 2015 Feb 11.

Abstract

Purpose: To determine the refractometric, keratometric and functional results 3 years after cross-linking therapy in patients with keratoconus.

Patients and methods: Eighty-one patients in various stages of keratoconus were studied, all meeting eligibility criteria for the cross-linking technique.

Results: The results showed a decrease both in the K-values, of about 1.5 D, and in the refraction. Visual acuity improved by 1, 2 or 3 Snellen lines in 70% of the cases.

Conclusions: The cross-linking technique is a modern method for stopping the progression of keratoconus.

Keywords: Collagène cornéen; Corneal collagen; Cross-linking technique; Cross-linking therapy; Keratoconus; Kératocône; Refractometry; Réfractométrie.

Publication types

  • Clinical Study

MeSH terms

  • Adolescent
  • Adult
  • Collagen / metabolism*
  • Corneal Stroma / drug effects
  • Corneal Stroma / metabolism*
  • Cross-Linking Reagents / therapeutic use*
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Humans
  • Keratoconus / drug therapy*
  • Male
  • Middle Aged
  • Polymerization
  • Prospective Studies
  • Refraction, Ocular / drug effects
  • Riboflavin / therapeutic use
  • Ultraviolet Therapy
  • Visual Acuity / drug effects
  • Young Adult

Substances

  • Cross-Linking Reagents
  • Collagen
  • Riboflavin