Abstract
Well-defined unnatural dipeptide-alcohols based on a cis-2,5-disubstitued pyrrolidine backbone were synthesized from commercially available starting materials meso-diethyl-2,5-dibromoadipate, (S)-(-)-1-phenylethylamine, and phenylalaninol. The structures of these unnatural dipeptide-alcohols are supported by HRMS, 1H- and 13C-NMR spectroscopy. These unnatural dipeptide-alcohols can act as building blocks for peptidomimetics.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adipates / chemistry
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Alcohols / chemical synthesis*
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Alcohols / chemistry*
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Crystallography, X-Ray
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Dipeptides / chemical synthesis*
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Dipeptides / chemistry*
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Peptidomimetics
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Phenethylamines / chemistry
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Phenylalanine / analogs & derivatives
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Phenylalanine / chemistry
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Pyrrolidines / chemistry*
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Stereoisomerism
Substances
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Adipates
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Alcohols
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Dipeptides
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Peptidomimetics
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Phenethylamines
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Pyrrolidines
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phenylalaninol
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Phenylalanine
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pyrrolidine