Staphylococcal infections in infants: updates and current challenges

Ana C Blanchard; Caroline Quach; Julie Autmizguine

doi:10.1016/j.clp.2014.10.013

Staphylococcal infections in infants: updates and current challenges

Clin Perinatol. 2015 Mar;42(1):119-32, ix. doi: 10.1016/j.clp.2014.10.013. Epub 2014 Nov 28.

Authors

Ana C Blanchard¹, Caroline Quach², Julie Autmizguine³

Affiliations

¹ Department of Pediatrics, CHU Sainte Justine, University of Montreal, 3175 Chemin Côte Sainte-Catherine, Montreal, Quebec H3T 1C5, Canada.
² Division of Infectious Diseases, Department of Medical Microbiology, The Montreal Children's Hospital, McGill University Health Centre, 2300 Tupper Street, Suite C1242, Montreal, Quebec H3H 1P3, Canada; Department of Pediatrics, The Montreal Children's Hospital, McGill University Health Centre, 2300 Tupper Street, Suite C1242, Montreal, Quebec H3H 1P3, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, 1020 Pine Avenue West, Montreal, Quebec H3A 1A2, Canada.
³ Department of Pediatrics, CHU Sainte Justine, University of Montreal, 3175 Chemin Côte Sainte-Catherine, Montreal, Quebec H3T 1C5, Canada; Department of Pharmacology, University of Montreal, 2900 Boulevard Edouard-Montpetit, Montreal, Quebec H3T 1J4, Canada; Research Center CHU Sainte-Justine, 3175 Chemin Côte Sainte Catherine, Montreal, Quebec H3T 1C5, Canada. Electronic address: julie.autmizguine@umontreal.ca.

PMID: 25678000
DOI: 10.1016/j.clp.2014.10.013

Abstract

Staphylococci are common pathogens in the neonatal period. Increased survival of premature infants leads to prolonged hospital stay with associated risk factors for developing invasive staphylococcal disease. Challenges of diagnosing coagulase-negative staphylococcal infections result in conflicting definitions and inconsistent clinical practice. Resistance to methicillin influences the choice of empirical therapy.

Keywords: Bloodstream infection; Coagulase-negative staphylococci; Heteroresistance; Infants; Neonatal intensive care unit; Resistance; Sepsis; Staphylococcus aureus.

Publication types

Review

MeSH terms

Anti-Bacterial Agents / therapeutic use*
Bacteremia / drug therapy*
Bacteremia / microbiology
Cross Infection
Humans
Infant
Infant, Newborn
Infant, Premature
Intensive Care Units, Neonatal
Methicillin Resistance
Methicillin-Resistant Staphylococcus aureus
Sepsis / drug therapy
Sepsis / microbiology
Staphylococcal Infections / drug therapy*
Staphylococcal Infections / microbiology
Staphylococcus aureus
Staphylococcus epidermidis

Substances

Anti-Bacterial Agents