OASL-a new player in controlling antiviral innate immunity

Curr Opin Virol. 2015 Jun:12:15-9. doi: 10.1016/j.coviro.2015.01.010. Epub 2015 Feb 9.

Abstract

The cellular innate immune system plays a crucial role in mounting the initial resistance to virus infection. It is comprised of various pattern-recognition receptors that induce type I interferon production, which further shapes the adaptive immunity. However, to overcome this resistance and promote replication, viruses have evolved mechanisms to evade this host innate immune response. Here we discuss a recently described mechanism of boosting the innate immunity by oligoadenylate synthetase-like (OASL) protein, which can potentially be used to overcome viral evasion and enhance innate immunity.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • 2',5'-Oligoadenylate Synthetase / chemistry
  • 2',5'-Oligoadenylate Synthetase / genetics
  • 2',5'-Oligoadenylate Synthetase / metabolism*
  • 2',5'-Oligoadenylate Synthetase / therapeutic use*
  • Adaptive Immunity
  • Animals
  • Gene Expression Regulation
  • Host-Pathogen Interactions
  • Humans
  • Immune Evasion
  • Immunity, Innate*
  • Receptors, Pattern Recognition / immunology
  • Signal Transduction
  • Viral Proteins / metabolism
  • Virus Diseases / immunology*
  • Virus Diseases / therapy
  • Virus Diseases / virology
  • Viruses / immunology*
  • Viruses / pathogenicity*

Substances

  • Receptors, Pattern Recognition
  • Viral Proteins
  • OASL protein, human
  • 2',5'-Oligoadenylate Synthetase