Nontuberculous mycobacterial infections in cystic fibrosis

Stacey L Martiniano; Jerry A Nick

doi:10.1016/j.ccm.2014.11.003

Nontuberculous mycobacterial infections in cystic fibrosis

Clin Chest Med. 2015 Mar;36(1):101-15. doi: 10.1016/j.ccm.2014.11.003.

Authors

Stacey L Martiniano¹, Jerry A Nick²

Affiliations

¹ Department of Pediatrics, Children's Hospital Colorado, University of Colorado Denver School of Medicine, 13123 East 16th Avenue, B-395, Aurora, CO 80045, USA. Electronic address: Stacey.Martiniano@childrenscolorado.org.
² Department of Medicine, National Jewish Health, University of Colorado Denver, 1400 Jackson Street, Denver, CO 80206, USA.

PMID: 25676523
DOI: 10.1016/j.ccm.2014.11.003

Abstract

Nontuberculous mycobacteria (NTM) are important emerging cystic fibrosis (CF) pathogens. Factors including the steady aging of the CF population, the apparent increase of NTM in the environment, and the potential for patient-to-patient transmission, may contribute to increased acquisition. Diagnosis of NTM disease is challenging due to disease overlap; thus, comprehensive care of the CF patient must be optimized to assess the clinical impact of the NTM (indolent versus active), and to improve response to treatment. The development of a CF-specific approach to the diagnosis and treatment of NTM infection is a research priority for the CF community.

Keywords: Atypical mycobacteria; Cystic fibrosis; Mycobacterium abscessus; Mycobacterium avium complex; Nontuberculous mycobacteria.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Coinfection
Cystic Fibrosis*
Humans
Mycobacterium Infections, Nontuberculous / complications
Mycobacterium Infections, Nontuberculous / diagnosis*
Mycobacterium Infections, Nontuberculous / drug therapy
Nontuberculous Mycobacteria / classification*