HSV cheats the executioner

Karen L Mossman; Sandra K Weller

doi:10.1016/j.chom.2015.01.013

HSV cheats the executioner

Cell Host Microbe. 2015 Feb 11;17(2):148-51. doi: 10.1016/j.chom.2015.01.013.

Authors

Karen L Mossman¹, Sandra K Weller²

Affiliations

¹ Departments of Biochemistry and Biomedical Sciences and Pathology and Molecular Medicine, Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8S 4K1, Canada.
² Department of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, CT 06030, USA. Electronic address: weller@uchc.edu.

PMID: 25674981
DOI: 10.1016/j.chom.2015.01.013

Abstract

In this issue of Cell Host & Microbe, Huang et al. (2015) and Guo et al. (2015), along with recent work by Wang et al. (2014), reveal that HSV ribonucleotide reductase has opposing activities in either inducing or preventing necroptosis, depending on the host species. This evolutionary twist underscores the importance of selective pressure in virus-host relationships.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Host-Pathogen Interactions / immunology*
Humans
Male
Protein Kinases / metabolism*
Receptor-Interacting Protein Serine-Threonine Kinases / metabolism*
Viral Proteins / metabolism*

Substances

Viral Proteins
Protein Kinases
Receptor-Interacting Protein Serine-Threonine Kinases

Abstract

Publication types

MeSH terms

Substances

Grants and funding