Double trouble: HIV latency and CTL escape

Matthew D Marsden; Jerome A Zack

doi:10.1016/j.chom.2015.01.008

Double trouble: HIV latency and CTL escape

Cell Host Microbe. 2015 Feb 11;17(2):141-2. doi: 10.1016/j.chom.2015.01.008.

Authors

Matthew D Marsden¹, Jerome A Zack²

Affiliations

¹ Department of Medicine, Division of Hematology and Oncology, University of California, Los Angeles, CA 90095, USA.
² Department of Medicine, Division of Hematology and Oncology, University of California, Los Angeles, CA 90095, USA; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095, USA. Electronic address: jzack@ucla.edu.

Abstract

HIV can enter a state of latency that allows it to persist for decades in antiretroviral drug-treated patients. In a recent Nature paper, Deng et al. (2015) show that this latent reservoir also contains a large number of cytotoxic T lymphocyte escape mutants, presenting another challenge to HIV cure efforts.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Animals
Female
Genes, Dominant / genetics*
Genes, Viral / genetics*
HIV-1 / genetics*
HIV-1 / immunology*
Humans
Male
Mutation / genetics*
T-Lymphocytes, Cytotoxic / immunology*
Virus Latency / immunology*

Abstract

Publication types

MeSH terms

Grants and funding