Abstract
A copper-mediated trifluoromethylthiolation of vinyl bromides has been developed. This method provides ready access to vinyl trifluoromethyl thioethers in good to high yields from simple, inexpensive starting materials. A broad substrate scope is achieved, and the reaction is compatible with various functional groups, including cyano, nitro, trifluoromethyl, alkoxy, amino, halide, and heterocyclic groups.
MeSH terms
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Catalysis
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Copper / chemistry*
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Halogens / chemistry*
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Heterocyclic Compounds / chemistry*
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Hydrocarbons, Fluorinated / chemical synthesis*
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Hydrocarbons, Fluorinated / chemistry
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Nitriles / chemistry*
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Sulfides / chemical synthesis*
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Sulfides / chemistry
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Vinyl Compounds / chemical synthesis*
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Vinyl Compounds / chemistry
Substances
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Halogens
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Heterocyclic Compounds
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Hydrocarbons, Fluorinated
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Nitriles
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Sulfides
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Vinyl Compounds
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Copper
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vinyl bromide