Haemoglobin-based oxygen carriers: indications and future applications

Mary Njoku; Deidre St Peter; Colin F Mackenzie

doi:10.12968/hmed.2015.76.2.78

Haemoglobin-based oxygen carriers: indications and future applications

Br J Hosp Med (Lond). 2015 Feb;76(2):78-83. doi: 10.12968/hmed.2015.76.2.78.

Authors

Mary Njoku¹, Deidre St Peter, Colin F Mackenzie

Affiliation

¹ Associate Professor in the Department of Anesthesiology, Department of Anesthesiology, Shock Trauma Anesthesiology Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.

PMID: 25671471
DOI: 10.12968/hmed.2015.76.2.78

Abstract

This article describes current oxygen-carrying solutions, four new products and new indications to increase the benefit/risk ratio of haemoglobin-based oxygen carriers compared to blood. Indications include when blood is not available, if blood is contaminated, is refused or contraindicated, and for organ preservation.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Anemia / therapy*
Blood Substitutes / therapeutic use*
Hemoglobins / therapeutic use*
Hemorrhage / therapy*
Humans
Maleimides
Polyethylene Glycols

Substances

Blood Substitutes
Hemoglobins
Maleimides
OxyVita
PolyHeme
maleimide-polyethylene glycol-modified hemoglobin, MP4
polynitroxylated pegylated hemoglobin
HBOC 201
Polyethylene Glycols