Copper(II) bromide-catalyzed intramolecular decarboxylative functionalization to form a C(sp(3))-O bond for the synthesis of furo[3,2-c]coumarins

Org Biomol Chem. 2015 Mar 28;13(12):3602-9. doi: 10.1039/c4ob02490g.

Abstract

An efficient and eco-friendly copper(II) bromide-catalyzed intramolecular decarboxylative functionalization to form a C(sp(3))-O bond for the synthesis of furo[3,2-c]coumarins has been developed. In this reaction, a copper(II) bromide-catalyzed intramolecular decarboxylative functionalization of α-carbonyl is successfully realized to generate an α-bromo carbonyl compound as a key intermediate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry
  • Bromides / chemistry*
  • Catalysis
  • Copper / chemistry*
  • Coumarins / chemical synthesis*
  • Coumarins / chemistry
  • Decarboxylation

Substances

  • Aldehydes
  • Bromides
  • Coumarins
  • cupric bromide
  • Copper