Abstract
During pregnancy, both the mother and fetus are vulnerable to environmental pollution by particulate matters and chemicals. Although the toxicity of free pollutants has been frequently reported, the impact of nanoparticle/pollutant adducts on the vulnerable pregnant population remains unclear. In this study, pregnant mice were orally exposed to Mg(OH)2 nanoflakes and nanoflakes adsorbed with Cr(VI) anions during the peri-implantation and organogenesis stages of pregnancy at doses that did not induce systemic toxicity or pregnancy complications. The nano-Mg(OH)2/Cr(VI) adducts formation reduced fetal developmental toxicity compared with the toxicity induced by the same concentration of free Cr(VI) anions.
Keywords:
Developmental toxicity; Nano-Mg(OH)(2)/Cr(VI) adduct; Pregnant mice.
Copyright © 2015 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adsorption
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Animals
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Bone Development / drug effects
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Bone and Bones / drug effects
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Bone and Bones / embryology
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Chromium / administration & dosage
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Chromium / chemistry*
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Chromium / pharmacokinetics
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Chromium / toxicity*
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Endoplasmic Reticulum / drug effects
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Female
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Fetal Development / drug effects
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Hyperplasia / chemically induced
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Magnesium Hydroxide / administration & dosage
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Magnesium Hydroxide / chemistry*
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Magnesium Hydroxide / pharmacokinetics
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Mice, Inbred ICR
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Mitochondria / drug effects
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Nanostructures / administration & dosage
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Nanostructures / chemistry*
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Placenta / drug effects
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Placenta / pathology
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Placenta Growth Factor
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Pregnancy
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Pregnancy Proteins / blood
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Pregnancy Proteins / metabolism
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Tissue Distribution
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Vascular Endothelial Growth Factor A / blood
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Vascular Endothelial Growth Factor A / metabolism
Substances
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Pgf protein, mouse
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Pregnancy Proteins
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Vascular Endothelial Growth Factor A
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vascular endothelial growth factor A, mouse
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Chromium
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Placenta Growth Factor
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chromium hexavalent ion
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Magnesium Hydroxide