First report of macrolide resistance gene erm(T) harbored by a novel small plasmid from Erysipelothrix rhusiopathiae

Antimicrob Agents Chemother. 2015 Apr;59(4):2462-5. doi: 10.1128/AAC.00228-15. Epub 2015 Feb 9.

Abstract

The macrolide resistance gene erm(T) was identified for the first time in a porcine Erysipelothrix rhusiopathiae isolate from swine in China. The novel 3,749-bp small plasmid pER29, which carries erm(T), had a G+C content of 31% and four distinct open reading frames. The presence of pER29 increased by at least 128-fold the MICs of clindamycin and erythromycin for E. rhusiopathiae. The fitness cost of pER29 could be responsible for the low frequency of erm(T) in E. rhusiopathiae.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / pharmacology*
  • Clindamycin / pharmacology
  • Drug Resistance, Bacterial / genetics*
  • Erysipelothrix / enzymology*
  • Erysipelothrix / genetics
  • Erysipelothrix Infections / microbiology
  • Erythromycin / pharmacology
  • Genes, Bacterial / genetics
  • Macrolides / pharmacology*
  • Microbial Sensitivity Tests
  • Open Reading Frames / genetics
  • Plasmids / genetics
  • Swine

Substances

  • Anti-Bacterial Agents
  • Macrolides
  • Clindamycin
  • Erythromycin