Minor secondary metabolites from the bark of Entandrophragma congoënse (Meliaceae)

Gervais Mouthé Happi; Simeon Fogue Kouam; Ferdinand Mouafo Talontsi; Sebastian Zühlke; Marc Lamshöft; Michael Spiteller

doi:10.1016/j.fitote.2015.01.018

Minor secondary metabolites from the bark of Entandrophragma congoënse (Meliaceae)

Fitoterapia. 2015 Apr:102:35-40. doi: 10.1016/j.fitote.2015.01.018. Epub 2015 Feb 7.

Authors

Gervais Mouthé Happi¹, Simeon Fogue Kouam², Ferdinand Mouafo Talontsi³, Sebastian Zühlke³, Marc Lamshöft³, Michael Spiteller⁴

Affiliations

¹ Department of Chemistry, Higher Teachers' Training College, University of Yaounde I, P. O. Box 47, Yaounde, Cameroon; Institute of Environmental Research (INFU) of the Faculty of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6, D-44221 Dortmund, Germany.
² Department of Chemistry, Higher Teachers' Training College, University of Yaounde I, P. O. Box 47, Yaounde, Cameroon. Electronic address: kfogue@yahoo.com.
³ Institute of Environmental Research (INFU) of the Faculty of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6, D-44221 Dortmund, Germany.
⁴ Institute of Environmental Research (INFU) of the Faculty of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6, D-44221 Dortmund, Germany. Electronic address: m.spiteller@infu.tu-dortmund.de.

PMID: 25665944
DOI: 10.1016/j.fitote.2015.01.018

Abstract

Two new tirucallane-type triterpenoids were isolated from the bark of Entandrophragma congoënse (Meliaceae) along with five known compounds gladoral A, bipendensin, 4-hydroxymethyl-3,5-dimethyldihydrofuran-2(3H)-one, scopoletin and 5,7-dimethoxy-6-hydroxycoumarin. Their structures were elucidated by means of spectroscopic analyses including 1D and 2D-NMR spectroscopy, high resolution mass spectrometric data as well as the comparison of data with those reported in the literature. The tested compounds (1-4) displayed moderated antiplasmodial activity against erythrocytic stages of chloroquine-resistant Plasmodium falciparum strain NF54 and low cytotoxicity on L6 cell lines. All the isolated compounds are reported for the first time from the genus Entandrophragma.

Keywords: Antiplasmodial; Cytotoxicity; Entandrophragma congoënse; Meliaceae; Triterpenoids.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antimalarials / chemistry
Antimalarials / isolation & purification
Cell Line
Meliaceae / chemistry*
Molecular Structure
Plant Bark / chemistry*
Plasmodium falciparum / drug effects
Rats
Triterpenes / chemistry*
Triterpenes / isolation & purification

Substances

Antimalarials
Triterpenes