The associations between triglyceride to high-density lipoprotein cholesterol ratios and the risks of gestational diabetes mellitus and large-for-gestational-age infant

Clin Endocrinol (Oxf). 2015 Oct;83(4):490-7. doi: 10.1111/cen.12742. Epub 2015 Mar 6.

Abstract

Objective: To evaluate the associations between triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratios and the risks of gestational diabetes mellitus (GDM) and delivering large-for-gestational-age (LGA) infant.

Design: This was a single-centre prospective observational study.

Patients: Six hundred and thirty-six women with a singleton pregnancy were recruited.

Measurements: Lipids profile, HbA1c and glucose were measured at the time of oral glucose tolerance test (OGTT) during 24-28 gestational weeks. TG/HDL-C ratios were calculated and clinical data including perinatal parameters were analysed.

Results: The prevalence of GDM was 17·30% (n = 110) and LGA was 3·93% (n = 25) in this study. TG/HDL-C ratios were found to be significantly higher in GDM group (P < 0·01) and LGA group (P = 0·045) compared with those in non-GDM group and non-LGA group, respectively. TG/HDL-C ratios were independently associated with the risks of GDM (OR = 1·64, P = 0·02) and LGA (OR = 2·87, P < 0·01). The area under the combined ROC curve of TG/HDL-C ratio and HbA1c to detect GDM was 0·705 (95% CI, 0·637-0·772). Furthermore, the area under the ROC curve of TG/HDL-C ratio combined with HbA1c and prepregnancy BMI to detect LGA was 0·806 (95% CI, 0·719-0·893).

Conclusions: TG/HDL-C ratios in combination with HbA1c and prepregnancy BMI can be good markers to predict the risks of GDM and delivering LGA infant.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Birth Weight / physiology*
  • Cholesterol, HDL / blood*
  • Diabetes, Gestational / blood*
  • Female
  • Glycated Hemoglobin / metabolism
  • Humans
  • Infant, Newborn
  • Male
  • Pregnancy
  • Prospective Studies
  • Triglycerides / blood*

Substances

  • Cholesterol, HDL
  • Glycated Hemoglobin A
  • Triglycerides