Siderochelins with anti-mycobacterial activity from Amycolatopsis sp. LZ149

Chun-Hua Lu; Fang-Wen Ye; Yue-Mao Shen

doi:10.1016/S1875-5364(15)60009-7

Siderochelins with anti-mycobacterial activity from Amycolatopsis sp. LZ149

Chin J Nat Med. 2015 Jan;13(1):69-72. doi: 10.1016/S1875-5364(15)60009-7.

Authors

Chun-Hua Lu¹, Fang-Wen Ye², Yue-Mao Shen³

Affiliations

¹ Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China. Electronic address: ahua0966@sdu.edu.cn.
² School of Life Sciences, Xiamen University, Xiamen 361005, china.
³ Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China; School of Life Sciences, Xiamen University, Xiamen 361005, china.

PMID: 25660291
DOI: 10.1016/S1875-5364(15)60009-7

Abstract

Three new compounds, namely siderochelins D (2), E (3), and F (4), together with one known siderochelin A (1), were isolated from Amycolatopsis sp. LZ149 and elucidated by spectroscopic analyses including1D- and 2D-NMR and X-ray single crystal diffraction. Compounds 1-3 showed antibacterial activity against Mycobacterium smegmatis.

Keywords: Amycolatopsis sp. LZ149; Bioassay-guided; Mycobacterium smegmatis; Siderochelin; X-ray single crystal diffraction.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Actinobacteria / chemistry*
Anti-Infective Agents / pharmacology*
Dihydropyridines / isolation & purification*
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Molecular Structure
Mycobacterium smegmatis / drug effects*

Substances

Anti-Infective Agents
Dihydropyridines
siderochelin A