Ascl2 reinforces intestinal stem cell identity

Kelley S Yan; Calvin J Kuo

doi:10.1016/j.stem.2015.01.014

Ascl2 reinforces intestinal stem cell identity

Cell Stem Cell. 2015 Feb 5;16(2):105-6. doi: 10.1016/j.stem.2015.01.014.

Authors

Kelley S Yan¹, Calvin J Kuo²

Affiliations

¹ Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
² Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: cjkuo@stanford.edu.

PMID: 25658363
DOI: 10.1016/j.stem.2015.01.014

Abstract

Ascl2 is a Wnt-responsive master transcription factor that controls the Lgr5(+) intestinal stem cell gene expression program. Now in Cell Stem Cell, Schuijers et al. (2015) report an Ascl2 positive feedback loop, tuned by previous Wnt pathway activity, that perpetuates intestinal stem cell identity in response to Wnt/R-spondin stimulation.

Publication types

Comment

MeSH terms

Animals
Basic Helix-Loop-Helix Transcription Factors / metabolism*
Intestinal Mucosa / cytology*
Intestinal Mucosa / metabolism*
Stem Cells / cytology*
Stem Cells / metabolism*
Thrombospondins / metabolism*
Wnt Signaling Pathway*

Substances

Basic Helix-Loop-Helix Transcription Factors
Thrombospondins

Abstract

Publication types

MeSH terms

Substances

Grants and funding