Changes in the default mode network in the prefrontal lobe, posterior cingulated cortex and hippocampus of heroin users

Wenfu Hu; Xiangming Fu; Ruobing Qian; Xiangpin Wei; Xuebing Ji; Chaoshi Niu

doi:10.3969/j.issn.1673-5374.2012.18.004

Changes in the default mode network in the prefrontal lobe, posterior cingulated cortex and hippocampus of heroin users

Neural Regen Res. 2012 Jun 25;7(18):1386-91. doi: 10.3969/j.issn.1673-5374.2012.18.004.

Authors

Wenfu Hu¹, Xiangming Fu², Ruobing Qian³, Xiangpin Wei³, Xuebing Ji⁴, Chaoshi Niu³

Affiliations

¹ Department of Neurosurgery, Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, Anhui Province, China.
² Department of Neurosurgery, Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, Anhui Province, China ; Department of Neurosurgery, Anhui Provincial Institute of Stereotactic Neurosurgery, Hefei 230001, Anhui Province, China.
³ Department of Neurosurgery, Anhui Provincial Institute of Stereotactic Neurosurgery, Hefei 230001, Anhui Province, China.
⁴ Department of MRI, Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, Anhui Province, China.

PMID: 25657671
PMCID: PMC4308788
DOI: 10.3969/j.issn.1673-5374.2012.18.004

Abstract

The default mode network is associated with senior cognitive functions in humans. In this study, we performed independent component analysis of blood oxygenation signals from 14 heroin users and 13 matched normal controls in the resting state through functional MRI scans. Results showed that the default mode network was significantly activated in the prefrontal lobe, posterior cingulated cortex and hippocampus of heroin users, and an enhanced activation signal was observed in the right inferior parietal lobule (P < 0.05, corrected for false discovery rate). Experimental findings indicate that the default mode network is altered in heroin users.

Keywords: default mode network; functional MRI; heroin user; independent component analysis; neural regeneration; resting state.