Peptide assembly integration of fibroblast-targeting and cell-penetration features for enhanced antitumor drug delivery

Adv Mater. 2015 Mar 18;27(11):1865-73. doi: 10.1002/adma.201404715. Epub 2015 Feb 4.

Authors

Tianjiao Ji¹, Yanping Ding, Ying Zhao, Jing Wang, Hao Qin, Xiaoman Liu, Jiayan Lang, Ruifang Zhao, Yinlong Zhang, Jian Shi, Ning Tao, Zhihai Qin, Guangjun Nie

Affiliation

¹ CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), 11 Beiyitiao, Zhongguancun, Beijing, 100190, China.

PMID: 25651789
DOI: 10.1002/adma.201404715

No abstract available

Keywords: cancer-associated fibroblast; cell-penetrating peptide; drug delivery; tumor penetration.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemistry*
Biological Transport
Cell Line, Tumor
Cell-Penetrating Peptides / chemistry
Cell-Penetrating Peptides / metabolism*
Doxorubicin / chemistry
Drug Carriers / chemistry
Drug Carriers / metabolism*
Fibroblasts / metabolism*
Human Umbilical Vein Endothelial Cells
Humans
Hydrophobic and Hydrophilic Interactions
Mice
Nanoparticles / chemistry

Substances

Antineoplastic Agents
Cell-Penetrating Peptides
Drug Carriers
Doxorubicin