Abstract
We discuss a case of severe respiratory depression in a child, with ultrarapid CYP2D6 genotype and obstructive sleep apnea syndrome, after taking tramadol for pain relief related to a day-case tonsillectomy.
Keywords:
respiratory depression; tramadol; ultrarapid CYP2D6.
Copyright © 2015 by the American Academy of Pediatrics.
MeSH terms
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Analgesics, Opioid / adverse effects
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Analgesics, Opioid / therapeutic use
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Child, Preschool
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Cytochrome P-450 CYP2D6 / drug effects
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Cytochrome P-450 CYP2D6 / genetics
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Cytochrome P-450 CYP2D6 / metabolism*
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Genotype
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Humans
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Male
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Pain, Postoperative / drug therapy
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Respiratory Insufficiency / enzymology
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Respiratory Insufficiency / etiology*
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Tonsillectomy
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Tramadol / adverse effects*
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Tramadol / therapeutic use
Substances
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Analgesics, Opioid
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Tramadol
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Cytochrome P-450 CYP2D6