Reductive arene ortho-silanolization of aromatic esters with hydridosilyl acetals

Chem Commun (Camb). 2015 Mar 4;51(18):3778-81. doi: 10.1039/c4cc09850a.

Abstract

This work describes the design and application of a single-pot, reductive arene C-H silanolization of aromatic esters for synthesis of ortho-formyl arylsilanols. This strategy involves a sequence of two transition metal (Ir and Rh)-catalyzed reactions for reductive arene ortho-silylation directed by hydridosilyl acetals and hydrolysis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Acetals / chemistry*
  • Catalysis
  • Esters
  • Hydrolysis
  • Iridium / chemistry
  • Oxidation-Reduction
  • Rhodium / chemistry
  • Silanes / chemistry*

Substances

  • Acetals
  • Esters
  • Silanes
  • Iridium
  • Rhodium