Hodgkin Lymphoma of the Nasopharynx: Case Report with Review of the Literature

Head Neck Pathol. 2015 Sep;9(3):369-75. doi: 10.1007/s12105-015-0611-7. Epub 2015 Feb 3.

Abstract

We report an uncommon case and histopathologic work-up of Hodgkin lymphoma of the nasopharynx in a 49-year old female patient who presented with a 2-year complaint of bilateral nasal congestion. Histologic study revealed a lymphocyte rich subtype of classic Hodgkin lymphoma. Immunohistochemical analysis revealed CD15, CD30, OCT-2, BOB.1, and MUM-1 expression by the neoplastic cells and a lack of expression of CD45, CD20, CD3, EMA, and EBER. The review of the literature showed that Hodgkin lymphoma of the nasopharynx is rare, the most common reported subtype is the mixed cellularity, and Hodgkin lymphoma of the nasopharynx has a favorable prognosis.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Biomarkers, Tumor / analysis
  • Female
  • Hodgkin Disease / pathology*
  • Humans
  • Immunohistochemistry
  • Middle Aged
  • Nasopharyngeal Neoplasms / pathology*

Substances

  • Biomarkers, Tumor