Influence of living cells (L929) on the biodegradation of magnesium-calcium alloy

Colloids Surf B Biointerfaces. 2015 Feb 1:126:603-6. doi: 10.1016/j.colsurfb.2015.01.015. Epub 2015 Jan 17.

Abstract

In this study, the influence of living cells (L929) on the in vitro degradation behaviour of a magnesium-calcium alloy was investigated using an electrochemical technique in the Eagle's minimum essential medium (EMEM) with 10% foetal bovine serum (FBS) under 5% CO2 atmosphere. The degradation of the alloy increased significantly in the medium containing the cells as compared to that without cells. Post-degradation analysis revealed localized degradation in the vicinity of the cells. It is suggested that the cell metabolic activity has induced local pH drop and as a result increased the alloy degradation.

Keywords: Biomaterials; Degradation; L929 cells; Magnesium.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alloys / chemistry
  • Alloys / metabolism*
  • Animals
  • Calcium / chemistry
  • Calcium / metabolism*
  • Cell Line
  • Cell Survival
  • Electrochemical Techniques
  • Hydrogen-Ion Concentration
  • Magnesium / chemistry
  • Magnesium / metabolism*
  • Mice

Substances

  • Alloys
  • Magnesium
  • Calcium