Naturally occurring plant isoquinoline N-oxide alkaloids: their pharmacological and SAR activities

Valery M Dembitsky; Tatyana A Gloriozova; Vladimir V Poroikov

doi:10.1016/j.phymed.2014.11.002

Naturally occurring plant isoquinoline N-oxide alkaloids: their pharmacological and SAR activities

Phytomedicine. 2015 Jan 15;22(1):183-202. doi: 10.1016/j.phymed.2014.11.002. Epub 2014 Nov 20.

Authors

Valery M Dembitsky¹, Tatyana A Gloriozova², Vladimir V Poroikov²

Affiliations

¹ Institute of Drug Discovery, P.O. Box 45289, Jerusalem 91451, Israel. Electronic address: iddrdo@gmx.com.
² Institute of Biomedical Chemistry, Russian Academy of the Medical Sciences, Moscow 119121, Russia.

PMID: 25636889
DOI: 10.1016/j.phymed.2014.11.002

Abstract

The present review describes research on novel natural isoquinoline alkaloids and their N-oxides isolated from different plant species. More than 200 biological active compounds have shown confirmed antimicrobial, antibacterial, antitumor, and other activities. The structures, origins, and reported biological activities of a selection of isoquinoline N-oxides alkaloids are reviewed. With the computer program PASS some additional SAR (structure-activity relationship) activities are also predicted, which point toward new possible applications of these compounds. This review emphasizes the role of isoquinoline N-oxides alkaloids as an important source of leads for drug discovery.

Keywords: Activities; Alkaloids; Antibacterial; Anticancer; Isoquinoline; SAR.

Publication types

Review

MeSH terms

Alkaloids / chemistry*
Alkaloids / pharmacology
Anti-Infective Agents / chemistry
Anti-Infective Agents / pharmacology
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / pharmacology
Drug Discovery
Isoquinolines / chemistry*
Isoquinolines / pharmacology
Molecular Structure
Structure-Activity Relationship

Substances

Alkaloids
Anti-Infective Agents
Antineoplastic Agents, Phytogenic
Isoquinolines
isoquinoline