Anti-diabetic molecules from Cycas pectinata Griff. traditionally used by the Maiba-Maibi

Phytomedicine. 2015 Jan 15;22(1):23-6. doi: 10.1016/j.phymed.2014.10.007. Epub 2014 Nov 6.

Abstract

Bioactivity guided chemical investigation on active anti-diabetic constituents of the fruits of Cycas pectinata Griff. (FCP) characterized EAFr-5 as the most potent sub fraction which significantly reduced the blood glucose level to normal in STZ induced diabetic rats. It was shown to contain the biflavonoids amentoflavone (1) and 2,3-dihydroamentoflavone (2) which exhibited significantly high inhibitory potency against α-glucosidase (IC50 8.09 ± 0.023 and 9.77 ± 0.032 μM, respectively) and α-amylase (IC50 73.6 ± 0.48 and 39.69 ± 0.39 μM, respectively). This is the first report of bioactivity guided isolation of anti-diabetic constituents from the traditionally used fruits of Cycas pectinata Griff.

Keywords: Cycas pectinata; Diabetes; Maiba-Maibi; α-Amylase; α-Glucosidase.

MeSH terms

  • Animals
  • Biflavonoids / metabolism
  • Biflavonoids / pharmacology*
  • Cycas / chemistry*
  • Diabetes Mellitus, Experimental / drug therapy*
  • Fruit / chemistry
  • Hypoglycemic Agents / pharmacology*
  • Inhibitory Concentration 50
  • Molecular Structure
  • Rats, Wistar
  • alpha-Amylases / antagonists & inhibitors
  • alpha-Amylases / metabolism
  • alpha-Glucosidases / metabolism

Substances

  • 2,3-dihydroamentoflavone
  • Biflavonoids
  • Hypoglycemic Agents
  • amentoflavone
  • alpha-Amylases
  • alpha-Glucosidases