HLA-DQA1, DQB1 and DRB1 alleles associated with Takayasu arteritis in the Chinese Han population

Hum Immunol. 2015 Apr;76(4):241-4. doi: 10.1016/j.humimm.2015.01.008. Epub 2015 Jan 27.

Abstract

Takayasu arteritis (TA) is a chronic large-vessel vasculitis of unknown etiology. Human leukocyte antigen (HLA) alleles play an important role in the development of TA. Sequence specific primer-polymerase chain reaction was used to detect 10 alleles of the HLA-DQA1 gene and 13 alleles of the HLA-DQB1, -DRB1 gene. A significant increase in the frequencies of DRB1(∗)07 (Pc<0.01, OR=3.44, CI: 2.15-5.52) was observed among TA patients compared with the control group. The significantly increased frequencies of the haplotype DQA1(∗)03:01-DQB1(∗)03:01-DRB1(∗)07 (Corrected P-values<0.01) were observed in TA patients. But in the analysis of clinical manifestations, there are no significant associations with the HLA-DRB1(∗)07 allele.

Keywords: Chinese Han population; DQA1; DQB1; DRB1; Takayasu arteritis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alleles
  • China
  • DNA Mutational Analysis
  • Female
  • Gene Frequency
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Genotype
  • HLA-DQ alpha-Chains / genetics*
  • HLA-DQ beta-Chains / genetics*
  • HLA-DRB1 Chains / genetics*
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Genetic
  • Takayasu Arteritis / genetics*
  • Young Adult

Substances

  • HLA-DQ alpha-Chains
  • HLA-DQ beta-Chains
  • HLA-DQA1 antigen
  • HLA-DQB1 antigen
  • HLA-DRB1 Chains