A dual colorimetric-ratiometric fluorescent probe NAP-3 for selective detection and imaging of endogenous labile iron(III) pools in C. elegans

Chem Commun (Camb). 2015 Mar 25;51(24):5001-4. doi: 10.1039/c4cc09798j.

Abstract

The discovery of an iron(III)-selective ratiometric fluorescent probe to detect and visualize endogenous labile iron pools in living organisms at the molecular level has been long awaited. Herein we report the first dual colorimetric and ratiometric fluorescent probe naphtho[2,1-b][1,10]phenanthroline for selective and 'direct' visualization of labile iron(III) pools in a multicellular organism, Caenorhabditis elegans.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Caenorhabditis elegans / chemistry*
  • Colorimetry*
  • Ferric Compounds / analysis*
  • Fluorescent Dyes / chemical synthesis
  • Fluorescent Dyes / chemistry*
  • Hep G2 Cells
  • Heterocyclic Compounds, 4 or More Rings / chemical synthesis
  • Heterocyclic Compounds, 4 or More Rings / chemistry*
  • Humans
  • Molecular Structure
  • Quantum Theory

Substances

  • Ferric Compounds
  • Fluorescent Dyes
  • Heterocyclic Compounds, 4 or More Rings
  • NAP-3 compound