Improvement of heart rate variability after decreased insulin resistance after sleeve gastrectomy for morbidly obesity patients

Jin-Ming Wu; Hwan-Jeu Yu; Hong-Shiee Lai; Po-Jen Yang; Ming-Tsan Lin; Feipei Lai

doi:10.1016/j.soard.2014.09.011

Improvement of heart rate variability after decreased insulin resistance after sleeve gastrectomy for morbidly obesity patients

Surg Obes Relat Dis. 2015 May-Jun;11(3):557-63. doi: 10.1016/j.soard.2014.09.011. Epub 2014 Oct 30.

Authors

Jin-Ming Wu¹, Hwan-Jeu Yu², Hong-Shiee Lai³, Po-Jen Yang³, Ming-Tsan Lin⁴, Feipei Lai⁵

Affiliations

¹ Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan.
² Department of Computer Science and Information Engineering, National Taiwan University, Taipei, Taiwan.
³ Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
⁴ Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address: linmt@ntu.edu.tw.
⁵ Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan.

PMID: 25630807
DOI: 10.1016/j.soard.2014.09.011

Abstract

Background: Morbidly obese patients display both an autonomic nervous imbalance and impaired glucose metabolism, and both of these conditions can be partially reversed after bariatric surgery. The aim of the present study was to investigate changes in heart rate variability (HRV) and glucose metabolism in patients after laparoscopic sleeve gastrectomy (SG).

Methods: Eighteen morbidly obese patients who underwent SG were examined before surgery and at 7, 30, 90, and 180 days after surgery. Indices of HRV included time-domain, frequency-domain, and nonlinear parameters. Glucose metabolism was evaluated by the measuring levels of insulin resistance, glycated hemoglobin (HbA(1c)), and gut hormones.

Results: The study included 9 men and 9 women with a mean age of 34 years. In the HRV study, the average R-R interval, median R-R interval, standard deviation of the R-R intervals, root mean squared successive difference of the R-R intervals (RMSSD), and the number of pairs of successive normal-to-normal beat intervals that differed by>50 ms significantly increased at 180 days after surgery. Regarding the frequency-domain indices, the low frequency (LF)/high frequency (HF) ratio was more balanced at 90 days after SG compared with baseline, and increases in the total power, LF band, and HF band were observed at 180 days. The assessments of insulin resistance, glucose metabolism, and gut hormones revealed not only improvements in the homeostasis model assessment of insulin resistance and HbA1c levels but also increases in the levels of glucagon-like peptide-1 at 90 and 180 days after surgery compared with baseline. A multivariable regression model revealed significantly negative associations between the perioperative changes in HOMA-IR and changes in both the RMSSD and HF band.

Conclusions: SG leads to early improvements in insulin resistance and glucose metabolism that are followed by improvements in HRV indices. Improvements in insulin resistance were associated with increases in the RMSSD and HF band index, but the mechanism of these changes require further study.

Keywords: Glucose metabolism; Heart rate variability; Sleeve gastrectomy.

MeSH terms

Adult
Blood Glucose / metabolism*
Body Mass Index
Circadian Rhythm / physiology*
Electrocardiography
Female
Follow-Up Studies
Gastrectomy / methods*
Glycated Hemoglobin / metabolism
Heart Rate / physiology*
Humans
Insulin Resistance / physiology*
Male
Obesity, Morbid / physiopathology
Obesity, Morbid / surgery*
Time Factors

Substances

Blood Glucose
Glycated Hemoglobin A