Enhancer trafficking: free throws and three-pointers

Yiliang Wei; David N Arnosti

doi:10.1016/j.devcel.2015.01.006

Enhancer trafficking: free throws and three-pointers

Dev Cell. 2015 Jan 26;32(2):135-7. doi: 10.1016/j.devcel.2015.01.006.

Authors

Yiliang Wei¹, David N Arnosti²

Affiliations

¹ Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA.
² Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA. Electronic address: arnosti@msu.edu.

PMID: 25625204
DOI: 10.1016/j.devcel.2015.01.006

Abstract

Accurate targeting of transcriptional enhancers to the correct promoter poses a significant information problem in higher eukaryotes. Enhancer-core promoter specificity may provide one solution. Reporting recently in Nature, Zabidi et al. (2014) uncover, via a genome-wide analysis approach, two general classes of enhancer-promoter interactions differentially regulating "housekeeping" versus "developmental" genes.

Publication types

Comment

MeSH terms

Animals
Drosophila melanogaster / embryology*
Drosophila melanogaster / genetics*
Enhancer Elements, Genetic / genetics*
Gene Expression Regulation, Developmental / genetics*
Genes, Essential / genetics*
Promoter Regions, Genetic / genetics*