The safety assessment of food ingredients derived from plant cell, tissue and organ cultures: a review

Hosakatte Niranjana Murthy; Milen I Georgiev; So-Young Park; Vijayalaxmi S Dandin; Kee-Yoeup Paek

doi:10.1016/j.foodchem.2014.12.075

The safety assessment of food ingredients derived from plant cell, tissue and organ cultures: a review

Food Chem. 2015 Jun 1:176:426-32. doi: 10.1016/j.foodchem.2014.12.075. Epub 2014 Dec 25.

Authors

Hosakatte Niranjana Murthy¹, Milen I Georgiev², So-Young Park³, Vijayalaxmi S Dandin⁴, Kee-Yoeup Paek³

Affiliations

¹ Research Centre for Development of Advanced Horticultural Technology, Chungbuk National University, Cheongju 361-763, Republic of Korea; Department of Botany, Karnatak University, Dharwad 580003, India. Electronic address: nmurthy60@yahoo.co.in.
² The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 139 Ruski Blvd, 4000 Plovdiv, Bulgaria.
³ Research Centre for Development of Advanced Horticultural Technology, Chungbuk National University, Cheongju 361-763, Republic of Korea.
⁴ Department of Botany, Karnatak University, Dharwad 580003, India.

PMID: 25624252
DOI: 10.1016/j.foodchem.2014.12.075

Abstract

Plant cell, tissue and organ cultures (PCTOC) have become an increasingly attractive alternative for the production of various high molecular weight molecules which are used as flavourings, fragrances, colouring agents and food additives. Although PCTOC products are cultivated in vitro in a contamination free environment, the raw material produced from PCTOC may contain many components apart from the target compound. In some cases, PCTOC raw materials may also carry toxins, which may be naturally occurring or accumulated during the culture process. Assessment of the safety of PCTOC products is, therefore, a priority of the biotech industries involved in their production. The safety assessment involves the evaluation of starting material, production process and the end product. Before commercialisation, PCTOC products should be evaluated for their chemical and biological properties, as well as for their toxicity. In this review, measures and general criteria for biosafety evaluation of PCTOC products are addressed and thoroughly discussed.

Keywords: Biosafety; Food ingredients; Phytochemicals; Plant cell tissue and organ culture products; Toxicological evaluation.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Consumer Product Safety / standards*
Food Additives
Hazard Analysis and Critical Control Points / methods*
Organ Culture Techniques / methods*
Phytochemicals
Plant Cells

Substances

Food Additives
Phytochemicals