Synthesis of oolongtheanins and their inhibitory activity on micellar cholesterol solubility in vitro

Kazuki Ogawa; Sayumi Hirose; Hitomi Yamamoto; Masaya Shimada; Satoshi Nagaoka; Emiko Yanase

doi:10.1016/j.bmcl.2015.01.002

Synthesis of oolongtheanins and their inhibitory activity on micellar cholesterol solubility in vitro

Bioorg Med Chem Lett. 2015 Feb 15;25(4):749-52. doi: 10.1016/j.bmcl.2015.01.002. Epub 2015 Jan 9.

Authors

Kazuki Ogawa¹, Sayumi Hirose¹, Hitomi Yamamoto¹, Masaya Shimada¹, Satoshi Nagaoka¹, Emiko Yanase²

Affiliations

¹ Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
² Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan. Electronic address: e-yanase@gifu-u.ac.jp.

PMID: 25619638
DOI: 10.1016/j.bmcl.2015.01.002

Abstract

The synthesis of oolongtheanins (1a-d) was accomplished from EGC and/or EGCg in three steps. Oolongtheanin-3'-O-gallate (1b) showed more potent inhibitory activity on micellar cholesterol solubility than did EGCg.

Keywords: Catechin; Cholesterol; Micelle; Oolongtheanins.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Benzopyrans / chemical synthesis
Benzopyrans / chemistry*
Camellia sinensis / chemistry
Catechin / chemistry*
Cholesterol / chemistry*
In Vitro Techniques
Micelles
Polyphenols / chemical synthesis
Polyphenols / chemistry*
Solubility

Substances

Benzopyrans
Micelles
Polyphenols
Catechin
Cholesterol