DNA Binding Test, X-Ray Crystal Structure, Spectral Studies, TG-DTA, and Electrochemistry of [CoX 2 (dmdphphen)] (Dmdphphen Is 2,9-Dimethyl-4,7-diphenyl-1,10-phenanthroline, X = Cl, and NCS) Complexes

Mousa Al-Noaimi; Mohammed Suleiman; Hany W Darwish; Ahmed H Bakheit; Muneer Abdoh; Iyad Saadeddin; Naveen Shivalingegowda; Neartur Krishnappagowda Lokanath; Odey Bsharat; Assem Barakat; Ismail Warad

doi:10.1155/2014/914241

DNA Binding Test, X-Ray Crystal Structure, Spectral Studies, TG-DTA, and Electrochemistry of [CoX 2 (dmdphphen)] (Dmdphphen Is 2,9-Dimethyl-4,7-diphenyl-1,10-phenanthroline, X = Cl, and NCS) Complexes

Bioinorg Chem Appl. 2014:2014:914241. doi: 10.1155/2014/914241. Epub 2014 Dec 29.

Affiliations

¹ Department of Chemistry, Hashemite University, Zarqa 13115, Jordan.
² Department of Chemistry, Science College, An-Najah National University, P.O. Box 7, Nablus, Palestine.
³ Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia ; Department of Analytical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt.
⁴ Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
⁵ Department of Physics, Science College, An-Najah National University, P.O. Box 7, Nablus, Palestine.
⁶ Institution of Excellence, Vijnana Bhavan, University of Mysore, Manasagangotri, Mysore 570 006, India.
⁷ Department of Studies in Physics, University of Mysore, Manasagangotri, Mysore 570 006, India.
⁸ Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia ; Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria 21321, Egypt.

Abstract

Two new neutral mixed-ligand cobalt(II) complexes, [CoCl2(dmdphphen)] 1 and [Co(NCS)2(dmdphphen)] 2, where dmdphphen is 2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline, were synthesized and characterized by an elemental analysis, UV-Vis, IR, TG/DTA, cyclic voltammetry CV, and single X-ray diffraction. Complex 2 crystallized as monoclinic with a space group P21/c. Co(II) ions are located in a distorted tetrahedral environment. TG/DTA result shows that these complexes are very stable and decomposed through one-step reaction. The two complexes exhibit a quasireversible one-electron response at -550 and 580 mV versus Cp2Fe/Cp2Fe(+), which has been assigned to Co(I)/Co(II) and Co(II)/Co(III) couples. Absorption spectral studies reveal that such complexes exhibit hypochromicity during their interaction with CT-DNA.