The neonatal Fc receptor does not modulate hepatitis C virus neutralization

J Gen Virol. 2015 May;96(Pt 5):1062-1066. doi: 10.1099/vir.0.000060. Epub 2015 Jan 22.

Abstract

The neonatal Fc receptor (FcRn) is the only receptor known to be able to transport IgG across cell barriers and may therefore modulate virus infection. FcRn is expressed efficiently in hepatocytes. We therefore investigated the possible involvement of an FcRn-dependent mechanism in hepatitis C virus (HCV) neutralization. Our study, in both HCV pseudoparticles and HCV in cell-culture models, showed that FcRn was not involved in the intracellular neutralization of HCV, in contrast to the situation observed for influenza A virus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Neutralizing / immunology*
  • Antibodies, Neutralizing / metabolism*
  • Antibodies, Viral / immunology*
  • Antibodies, Viral / metabolism*
  • Hepacivirus / immunology*
  • Histocompatibility Antigens Class I / metabolism*
  • Humans
  • Infant, Newborn
  • Neutralization Tests
  • Receptors, Fc / metabolism*

Substances

  • Antibodies, Neutralizing
  • Antibodies, Viral
  • Histocompatibility Antigens Class I
  • Receptors, Fc
  • Fc receptor, neonatal