[Intracranial hemorrhage in three haemophilic adults: A severe complication of hemophilia]

Rev Neurol (Paris). 2015 Apr;171(4):367-72. doi: 10.1016/j.neurol.2014.10.017. Epub 2015 Jan 19.
[Article in French]

Abstract

Background: Intracranial hemorrhage (ICH) complications are uncommon at hemophilic patients.

Observations: We report three cases of ICH occurring in hemophilic patients. Contributing factors were identified in two patients: hemophilia severity, presence of inhibitor, hepatitis C virus infection, and high blood pressure. No contributing factor was identified in the last patient.

Conclusion: Rapid diagnosis of ICH is crucial in hemophilic patients. A search for contributing factors, both those specific to hemophilia, and those favoring ICH in the general population, is essential to optimize therapeutic care. Specific substitutive treatment for the deficient factor is a difficult management challenge.

Keywords: Contributing factors; Facteurs favorisant; Hemophilia; Hémophilie; Hémorragie intracérébrale; Intracranial hemorrhage; Prise en charge thérapeutique; Therapeutic care.

Publication types

  • Case Reports
  • English Abstract
  • Review

MeSH terms

  • Adult
  • Factor IX / analysis
  • Factor VIIa / therapeutic use
  • Hemophilia A / complications*
  • Hepatitis C / complications
  • Humans
  • Hypertension / complications
  • Intracranial Hemorrhages / etiology*
  • Male
  • Middle Aged
  • Thalamus / pathology
  • Treatment Outcome

Substances

  • Factor IX
  • Factor VIIa