The determination of the absolute configuration of a chiral 2,3'-diindolylarylmethane by NMR spectroscopy

Shuai Qi; Chuan-Qing Kang; Fu-She Han

doi:10.1002/mrc.4192

The determination of the absolute configuration of a chiral 2,3'-diindolylarylmethane by NMR spectroscopy

Magn Reson Chem. 2015 Mar;53(3):181-7. doi: 10.1002/mrc.4192. Epub 2015 Jan 22.

Authors

Shuai Qi¹, Chuan-Qing Kang, Fu-She Han

Affiliation

¹ Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, Jilin, 130022, China; The University of Chinese Academy of Sciences, Beijing, 100864, China.

PMID: 25612164
DOI: 10.1002/mrc.4192

Abstract

We present the determination of the absolute configuration of a chiral 2,3'-diindolylarylmethane 1 by using the combination of NMR spectroscopic and circular dichroism techniques. The results would be useful for the future study of the effect of chirality on the biological activity of 2,3'-diindolylarylmethanes.

Keywords: 1H; 2,3′-diindolylarylmethane; CD spectrum; Mosher's model; NMR; absolute configuration; α-methoxyphenylacetic acid (MPA).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Magnetic Resonance Spectroscopy / methods*
Methane / analogs & derivatives*
Methane / chemistry
Models, Molecular
Stereoisomerism

Substances

Methane